2017 Publications

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Ladner T., Mühlmann M., Schulte A., Wandrey G. and Büchs J.
Prediction of Escherichia coli expression performance in microtiter plates by analyzing only the temporal development of scattered light during culture
Based on slope at and time of the inflection point, predictions of the standardized expression performance are possible and for a first screen elaborated offline analysis can be avoided; based on 625 E. coli cultures.
Journal of Biological Engineering, 2017, 11:20; DOI: 10.1186/s13036-017-0064-5
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Hosseini R., Kuepper J., Koebbing S., Blank L.M., Wierckx N. and de Winde J.h
Regulation of solvent tolerance in Pseudomonas putidaS12 mediated by mobile elements
The genome of P. putida S12 was sequenced. The mobile genetic elements are described and elaborated on the role of ISS12 in the establishment and maintenance of solvent tolerance in P. putida.
Microbial Biotechnology (2017), doi: 10.1111/1751-7915.12495
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Gupta A., Brockman Reizman I., Reisch C. and Prather K.
Dynamic regulation of metabolic flux in engineered bacteria using a pathway-independent quorum-sensing circuit
The optimal point was identified to redirect glycolytic flux into heterologous engineered pathways in Escherichia coli, resulting in titers of myo-inositol increased 5.5-fold and titers of glucaric acid increased from unmeasurable to >0.8 g/L, compared to the parent strains lacking dynamic flux control.
Nature Biotechnology (2017); doi:10.1038/nbt.3796
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Mühlmann M, Kunze M., Ribeiro J., Geinitz B., Lehmann C., Schwaneberg U., Commandeur U. and Büchs J.
Cellulolytic RoboLector – towards an automated high-throughput screening platform for recombinant cellulase expression
An extended robotic platform is presented to conduct automated high-throughput screenings of clone libraries including preculture synchronization and biomass specific induction. Model organisms: E. coli and K. lactis.
Journal of Biological Engineering (2017), 11:1; doi: 10.1186/s13036-016-0043-2
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Morschett, H., Schiprowski, D., Rohde, J. et al.
Comparative evaluation of phototrophic microtiter plate cultivation against laboratory-scale photobioreactors
Evaluation of the scalability of a microtiter plate-based parallelized micro-photobioreactor against a representative set of established laboratory photobioreactors. Model system: Lipid production by Chlorella vulgaris
Bioprocess Biosyst Eng (2017); doi: 10.1007/s00449-016-1731-5
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