References

Denmark

DTU Technical University of Denmark
Lyngby
Dr. Ali Altıntaş

"I have been working with BioLector almost for 4 years and it was always such a great data we generated with it due to its high-throughput functionality. The ease of operation, experimental setup and light scattering based growth measurements makes BioLector one of the best micro-fermentation platforms in the market. During these 4 years, m2p-labs have always been so supportive that my orders were delivered fast and we had an awesome technical support. What I mostly like is that I got a quick response from m2p-labs whenever I needed their urgent help. For these reasons, I am really glad to work with m2p-labs (and BioLector, surely) and I believe they are a great example how a company should deal with their customers."

→ DTU

France

Université de Lille, Team ProBioGEM
Villeneuve d'Ascq
François COUTTE, Ph.D.

"We work with the Biolector for 2 years and this micro-fermentation system in parallel has clearly revolutionized the way we work and define our experiments.
Easy to use, results reproducibility and its friendly computer interface make the Biolector a powerful tool for the screening of bacterial and yeast strains, optimization of the medium composition and of the culture conditions. The online measurements of biomass growth, pH, dissolved oxygen and fluorescens have allowed us to deepen our knowledge of our models strains with an unexpected speed. 

In addition, technical assistance of the m2p-labs and their availability has always been faultless. In conclusion, we are so pleased with this system that we have planned to purchase the Pro version."

→ Lille University

Germany

DECHEMA-Forschungsinstitut
Frankfurt am Main
B. Sc. Ina Huth

"The BioLector has become an essential part of our everyday laboratory life. We use it for a wide range of applications and due to its robustness and compact design it can be easily transported as well. The moisture control function allows us to perform miniaturized long-term cultivations without the regular losses caused by evaporation. This is indispensable for fungi and other slow-growing organisms. The on-line monitoring of data on pH, biomass and oxygen supply is a helpful tool for the comprehension of cultivation processes. In summary, the BioLector, supplemented by the friendly and competent service of m2p-labs, is a modern, reliable and easy-to-use microfermentation system."

→ DECHEMA

FH Bielefeld, WG Fermentation and Formulation of Biologicals and Chemicals
Bielefeld
Dr. sc. agr. Rieke Lohse

"In 2013, I ran into the fully-automated microbioreactor system from m2p-labs at a conference and I was instantly impressed from the RoboLector® with an integrated BioLector Pro.
Because it is essential to investigate how culture conditions affect biomass or (secondary) metabolite production. The current practice to understand the influence of culture conditions from microorganisms on the production biomass as well as metabolites is still cost and time intensive. The fully-automated RoboLector allows 48 parallel batch or 32 fed-batch cultivations in a volume under 1 mL, which saves us a lot of time and money. Furthermore, the options to control shaking speed, temperature, pH and humidity during the cultivation combined with the non-invasive detection of pO2, biomass and product concentration accelerates the process to achieve optimal product yields enormously.

Afterwards, the knowledge gained from the fermentations on microscale facilitates the scale-up to an in vitro mass production process in a stirred tank reactor. Two years after the first meeting, the novel microbioreactor system was granted within the framework of “FHInvest2014” by the Federal Ministry of Education and Research as well as the Ministry of Innovation, Science, Research and Technology of North Rhine Westphalia (FKZ 03FH016IN4). Now, we are very happy that the RoboLector finally arrived in our lab in 2016.

Finally, I would like to mention that the support from m2p-labs is continuously available, very competent, always friendly and helpful."

→ FH Bielefeld

Forschungszentrum Jülich (FZJ)
Jülich
Dr. Simon Unthan

"We have continuously used the BioLector for years and are fully persuaded about this device. The results obtained are highly reproducible and the online analytics of parallel cultivation allows the rapid response to basic questions of the daily laboratory work. We are also very satisfied with the fast and competent support by the m2p-labs team."

→ FZ-Jülich

Hochschule Darmstadt, University of Applied Sciences
Darmstadt
Ms. Tina Uhlmer

"In my Bachelor Thesis it was the first time I worked with the BioLector – and I was immediately enthused! No more need of time-consuming and inconvenient cultures in shaking flasks for my tests! It was such an enormous saving of time because I could do numerous experiments simultaneously. The measurement of O.D. (biomass), pH and oxygen concentration was completely automatic - and thanks to the online monitoring I could control the progress of my experiments constantly.

Moreover I needed so little amounts of medium that the costs of my tests were reduced seriously! The analysis of the measured data was facilitated immensely by the software BioLection – and when I though had a question the pleasant m2p labs support team helped my with a fast and competent answer! The BioLector is a very beneficial and user friendly micro reactor that affords high throughput experiments as well as time saving and reducing costs at once!"

→ HS Darmstadt

Hochschule Trier, Umwelt-Campus Birkenfeld, Institut für biotechnisches Prozessdesign (IBioPD)
Trier
Prof. Dr.-Ing. Percy Kampeis

"The RoboLector enables us to optimize fermentation media fast and cost-effective. The combination of media preparation and parallel fermentations in microtiter plates is a useful tool in the development of new biotechnical processes."

→ HS Trier

KIT Karlsruhe Institute of Technology, Biomolecular Separation Engineering Group
Karlsruhe
Dr.-Ing. Pascal Baumann

"The BioLector was the central cultivation equipment during my doctoral thesis and became a standard tool for optimizing bacterial product formation in our academic group. The reproducibility of data and the easy way of scaling up microbial culture conditions makes the technology outstanding in the upstream sector. The vast number of screening possibilities enabled the generation of different cell lysates for a deeper lysate characterization. The BioLector has proven to be highly valuable for our institute and even enabled an integrated optimization of up- and downstream. m2p-labs having been part of our project team is always a friendly, competent and reliable partner."

→ KIT

Poland

technopark
Lodz
Dr. Krystof Makowski

"We have bought BioLector as a first company in Poland. At the beginning, we were full of doubts about its precision and repetitiveness. After few internal and commercial cultures we are pretty sure it was a good decision. Apart from previously mentioned features, time and media savings were other key points for us and our customers when we were looking for a system for parallel fermentations.

Easy to operate interface, data acquisition and presentation mode is a great advantage. From our point of view it is very useful tool for optimization of media composition, especially that results obtained in BioLector are almost identical with results obtained in a classical bioreactor systems. It is just the beginning of our adventure with BioLector and we are still looking for more fields of its application."

→ Nanoparc

United Kingdom

Biocatalysts Ltd.
Cardiff
Mark Blight

"Fermentation process development is a key requisite to Biocatalysts enzyme production platforms for the development of robust and reproducible fermentations of a variety of microbial organisms and recombinant expression systems. The process development for one of our major customer products was achieved through a large number of 1 to 3L fermentations over a period of about 18 months. We tested the Biolector shortly after this process was developed. The same process parameters were investigated in a series of two Flowerplate experiments, combined with DoE data analysis. Within 2 weeks we had identified the same key process parameters that we had achieved in 18 months with more traditional approaches.

Since then, and after purchasing the system, Biocatalysts Ltd. has used the Biolector on multiple customer and strategic projects requiring fermentation process development. These projects include media development, key fermentation parameter identification and refinement, strain selection and clonal screening. Data acquisition, interpretation and reproducibility have been extremely consistent and in one case we achieved scale-up from a 1 mL Flowerplate experiment to a 50L fermentation with consistent product yield. The equipment has proved to be reliable and robust in the 3 years we have been operating the unit.

The customer support from m2p-labs has been exemplary and professional. The introduction of the Biolector into fermentation process development at Biocatalysts Ltd. has significantly increased both reproducibility and experimental turnaround and reduced overall process development time and cost. This equipment has become a key part of our technology platform and in one customer project, was decisive in obtaining the contract."

→ Biocatalysts

Dr. Reddy’s Laboratories
Cambridge
Neil Triggs

"My team and I have been using the RoboLector system supported by m2p-labs for over a year. We selected the RoboLector system because it offered the best package of technology to increase our fermentation process development capability. Since the Robolector installation it has proven its worth assisting fermentation scientists, molecular biologists and chemists to increase experimental throughput significantly and generate better quality data. Automated precision sampling and feeding of controlled 48-well microbial culture has enabled us to achieve many project milestones significantly quicker than anticipated.

The RoboLector has allowed us to build complex statistical (DoE) models, including screening designs and optimisation designs for media development and early stage parameter development with ease, and such have been successfully scaled into stirred tank reactors with minimal adjustment. The use of the RoboLector online data monitoring of pH, DO, Biomass, productivity (GFP, RFP detection) and analysis software has provided better data than orbital shaking culture and so has significantly reduced routine flask work. The disposable technology means quick set-up and no clean-down times for fermentation.

The technical support from m2p-labs has been high quality and customer focussed. This technology would be useful to anyone wishing to increase their fermentation development capability and general data quality for all mandatory microbial cultivation within a small footprint."

→ Dr. Reddy's

UCL University College London, BahlerLab Genome Regulation
London
Jürg Bähler

"We have used the BioLector in our laboratory for over 4 years now, and this instrument has served us exceedingly well. It is easy to use, versatile and provides accurate, reproducible results. In no time, the BioLector has become a trusted and favourite ‘gatchet’, much used by almost everyone in the group. We have published results from BioLector experiments in 5 papers already, with more in the pipeline. The level of support and service we are receiving from m2p-labs is also very impressive. So we are very happy with the BioLector, and gladly recommend this gem of German engineering."

→ UCL Bahler Lab

USA

Duke University
Durham, NC
Ashley Trahan

"I have used the BioLector Basic from m2p-labs for the last year, and the instrument has more than met our expectations for high throughput strain evaluations. Our lab evaluates a diverse set of strains for the bioproduction of 30+ products, and the BioLector is central to learning and understanding this wide range of microbial systems. I find that the instrument and accessories are smartly designed, easy to understand and navigate, and use thorough and thoughtful software for both experimental design and data analysis. The customer and technical support is excellent, ranging from consultation with one of the founding scientists to competent applications and customer service staff. The BioLector has become an essential tool for our lab, and expansion and diversification using m2p-labs products in definitely in our future!"

→ Duke

MIT Massachusetts Institute of Technology
Cambridge, MA
Kristala L. Jones Prather, Irene M. Brockman, Christopher R. Reisch

"The BioLector has been a useful tool both for process optimization and for E. coli strain design in our laboratory. On the bioprocess side, we have screened media formulations in order to develop media compositions limited in specific nutrients. The automatic OD monitoring in the BioLector saves labor and allows us to closely monitor growth patterns such as diauxic shifts that may be less apparent with infrequent sampling. We have also found the BioLector valuable for monitoring of small-molecule production and screening of promoter and RBS libraries during strain development. We see high consistency in production titers in the BioLector in E. coli, and also good sensitivity when monitoring GFP production from test constructs."

→ MIT