Strain engineering inthe laboratory often does not consider process requirements in larger-scale bioreactors. Systems and synthetic biology can be applied to design microbial strains that allow reliable and robust production on a large scale.Commercial microbial platforms should be selected and developed based on their relevance to final process goals.
Trends in Microbiology, 2019 (TIMI 1664 No. of Pages 14), DOI: https://doi.org/10.1016/j.tim.2019.01.006 Go to publication
Culture contamination, end-product toxicity, and energy efficient product recovery are long-standing bioprocess challenges. The solution - a high-pressure fermentation strategy, coupled with in situ extraction using the abundant and renewable solvent supercritical carbon dioxide (scCO2), which is also known for its broad microbial lethality.
Nature Communications (2019) 10:587, https://doi.org/10.1038/s41467-019-08486-6 Go to publication